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nix-plist-manager

Shortcut

Everything under System Settings › Accessibility › Shortcut, as Nix options. Each one is named after the control you'd click, and set under programs.nix-plist-manager.options in home-manager.

1 option 1 verified against System Settings

Speech

Section titled “Speech”

System Settings › Accessibility › Shortcut › Speech

home-manager · per user ✓ Verified on macOS 27 
applications.systemSettings.accessibility.shortcut.speech = true;

true or false "unset" puts back macOS's default.

Where it's stored and what runs
  • com.apple.universalaccess axShortcutSpeechEnabled

For false:

/usr/bin/defaults write com.apple.universalaccess axShortcutSpeechEnabled -bool false || echo 'nix-plist-manager: failed: /usr/bin/defaults write com.apple.universalaccess axShortcutSpeechEnabled -bool false' >&2
/usr/bin/defaults -currentHost delete com.apple.universalaccess axShortcutSpeechEnabled 2>/dev/null || true

For true:

/usr/bin/defaults write com.apple.universalaccess axShortcutSpeechEnabled -bool true || echo 'nix-plist-manager: failed: /usr/bin/defaults write com.apple.universalaccess axShortcutSpeechEnabled -bool true' >&2
/usr/bin/defaults -currentHost delete com.apple.universalaccess axShortcutSpeechEnabled 2>/dev/null || true

For unset:

/usr/bin/defaults delete com.apple.universalaccess axShortcutSpeechEnabled 2>/dev/null || true
/usr/bin/defaults -currentHost delete com.apple.universalaccess axShortcutSpeechEnabled 2>/dev/null || true